Cyclo-oxygenase-2 Plays a Critical Role in UV-induced Skin Carcinogenesis
نویسندگان
چکیده
منابع مشابه
Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis
TREX2 is a 3'-DNA exonuclease specifically expressed in keratinocytes. Here, we investigated the relevance and mechanisms of TREX2 in ultraviolet (UV)-induced skin carcinogenesis. TREX2 expression was up-regulated by chronic UV exposure whereas it was de-regulated or lost in human squamous cell carcinomas (SCCs). Moreover, we identified SNPs in the TREX2 gene that were more frequent in patients...
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ژورنال
عنوان ژورنال: Photochemistry and Photobiology
سال: 2008
ISSN: 0031-8655,1751-1097
DOI: 10.1111/j.1751-1097.2007.00261.x